It works by mimicking the natural GHRH peptide 1 , which is produced in the hypothalamus, to stimulate the release of growth hormone (GH) from the pituitary gland
The Hormone Powering Weight Loss Medications In the world of modern medicine, few discoveries have generated as much excitement in recent years as glucagon-like peptide-1 (GLP-1)
doi:10.3389/fimmu.2015.00270
For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies
Nature 444 , 756760 (2006)
In those scenarios the copper load is far less predictable, and there are no controlled human dosing studies establishing a safe threshold